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Reconstructive challenge of dermatofibrosarcoma protuberans in the female breast

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Abstract Dermatofibrosarcoma protuberans is an uncommon locally aggressive malignant neoplasm that most frequently appears in the trunk, followed by the extremities, head, and neck. But occurrence in the breast is extremely rare. We present a case of a 28-year-old woman, who had a history of trauma 5 years previously and excision 1 year before presentation at our clinic. We performed wide excision, together with microscopic and immunohistochemical analysis. No postoperative oncologic treatment was used and she remains disease-free 1 year after the surgery without any tumor recurrence. Here, we report a case of dermatofibrosarcoma protuberans in the female breast and. | Park et al. World Journal of Surgical Oncology 2011 9 1 http www.wjso.eom content 9 1 1 WORLD JOURNAL OF SURGICAL ONCOLOGY CASE REPORT Open Access Reconstructive challenge of dermatofibrosarcoma protuberans in the female breast Tae Hwan Park Sang Won Seo June Kyu Kim Choong Hyun Chang Abstract Dermatofibrosarcoma protuberans is an uncommon locally aggressive malignant neoplasm that most frequently appears in the trunk followed by the extremities head and neck. But occurrence in the breast is extremely rare. We present a case of a 28-year-old woman who had a history of trauma 5 years previously and excision 1 year before presentation at our clinic. We performed wide excision together with microscopic and immunohistochemical analysis. No postoperative oncologic treatment was used and she remains disease-free 1 year after the surgery without any tumor recurrence. Here we report a case of dermatofibrosarcoma protuberans in the female breast and present a detailed discussion of the diagnosis and treatment with reference to available literatures. Background Dermatofibrosarcoma protuberans DFSP is an uncommon slow-growing low-grade sarcoma of putative dermal fibroblastic origin 1 . DFSP was first described by Darier and Ferrand in 1924 and was referred to as a progressive and recurrent dermatofibroma. It was later officially termed dermatofibrosarcoma protuberans by Hoffmann in 1925 2 . DFSP is a clinically challenging neoplasm because it is characterized by a high recurrence rate with a high propensity for local invasion. In addition it is difficult to make a correct preoperative diagnosis because DFSP is often left untreated for several years probably due to its benign appearance and initial indolent behaviour. Our case highlights two specific features. First understanding the natural history of this entity is crucial even though there are potential difficulties in the diagnosis of DFSP owing to its rarity. Second reconstruction for aesthetic purpose can be delayed .