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báo cáo khoa học: "A Study to investigate the role of p27 and Cyclin E immunoexpression as a prognostic factor in early breast carcinoma"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: A Study to investigate the role of p27 and Cyclin E immunoexpression as a prognostic factor in early breast carcinoma | Pillay et al. World Journal of Surgical Oncology 2011 9 31 http www.wjso.eom content 9 1 31 5 2 WORLD JOURNAL OF SURGICAL ONCOLOGY RESEARCH Open Access A Study to investigate the role of p27 and Cyclin E immunoexpression as a prognostic factor in early breast carcinoma 1 1 2 1 Komala Pillay Heather McCleod Runjan Chetty Pauline Hall Abstract Background Cyclin E and p27 expression is easy to assess in human tissues by standard immunohistochemical techniques. Immunohistochemistry is cost effective relatively easy to perform and will play more of a role in the future management of cancer. The aim of this study was to investigate the role of p27 and cyclin E immunoexpression as a prognostic factor in early breast carcinoma. Methods Cyclin E and p27 immunohistochemistry was performed on sixty six cases of breast carcinoma submitted over a five year period to the Division of Anatomical Pathology Groote Schuur hospital Whittaker and Associates and PathCare. All tumours included in this study were less than 5 cm in diameter pT1 and pT2 stage and all the patients had wide local excisions performed. Follow up information was obtained from patient folders in the Department of Radiation Oncology. Results There was no significant association of cyclin E and p27 expression with distant metastasis free survival MFS for all invasive carcinomas in contrast to grade lymph node spread and vascular invasion. However there was a statistically significant direct association of cyclin E with distant metastases in all invasive carcinomas in the subgroup of infiltrating duct carcinomas IDC and in the node negative group when cyclin E was stratified as negative and positive low high . In this study of early breast carcinoma only 9 66 cases showed cyclin E expression. Of these four patients had distant metastases one patient had a local recurrence and four patients were alive at last follow-up. Furthermore cyclin E expression was significantly associated with grade lymph node spread .