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Báo cáo khoa học: "Genomic alterations of primary tumor and blood in invasive ductal carcinoma of breast"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Genomic alterations of primary tumor and blood in invasive ductal carcinoma of breast | Bae et al. World Journal of Surgical Oncology 2010 8 32 http www.wjso.eom content 8 1 32 WORLD JOURNAL OF SURGICAL ONCOLOGY RESEARCH Open Access Genomic alterations of primary tumor and blood in invasive ductal carcinoma of breast 12 2 1 1 13 Ja Seong Bae Jin Soo Choi Seung Ho Baik Woo Chan Park Byung Joo Song Jeong Soo Kim Young Lim Sang Seol Jung1 Abstract Background Genomic alterations are important events in the origin and progression of various cancers with DNA copy number changes associated with progression and treatment response in cancer. Array CGH is potentially useful in the identification of genomic alterations from primary tumor and blood in breast cancer patients. The aim of our study was to compare differences of DNA copy number changes in blood and tumor tissue in breast cancer. Methods DNA copy number changes in blood were compared to those in tumor tissue using array-comparative genomic hybridization in samples obtained from 30 breast cancer patients. The relative degree of chromosomal changes was analyzed using log2 ratios and data was validated by real-time polymerase chain reaction. Results Forty-six regions of gains present in more than 30 of the tissues and 70 regions of gains present in more than 30 of blood were identified. The most frequently gained region was chromosome 8q24. In total agreement of DNA copy numbers between primary tumor and blood was minimal Kappa 0.138 p 0.001 . Conclusion Although there was only a slight agreement of DNA copy number alterations between the primary tumor and the blood samples the blood cell copy number variation may have some clinical significance as compared to the primary tumor in IDC breast cancer patients. Background Breast cancer is the most frequently occurring malignancy in Korean women 1 . Even with advances in diagnosis and treatment of breast cancer the prognosis and survival of patients with breast cancer remains unsatisfactory. Histological and molecular heterogeneity of breast cancer even in .