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Báo cáo khoa học: "The clinical behavior of mixed ductal/lobular carcinoma of the breast: a clinicopathologic analysis"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: The clinical behavior of mixed ductal/lobular carcinoma of the breast: a clinicopathologic analysis | Suryadevara et al. World Journal of Surgical Oncology 2010 8 51 http www.wjso.eom content 8 1 51 WORLD JOURNAL OF SURGICAL ONCOLOGY RESEARCH Open Access The clinical behavior of mixed ductal lobular carcinoma of the breast a clinicopathologic analysis Aparna Suryadevara41 Lakshmi P ParuchurC1 Nassim Banisaeed2 Gary Dunnington3 5 and Krishna A Rao 4 5 Abstract Background To date the clinical presentation and prognosis of mixed ductal lobular mammary carcinomas has not been well studied and little is known about the outcome of this entity. Thus best management practices remain undetermined due to a dearth of knowledge on this topic. Methods In this paper we present a clinicopathologic analysis of patients at our institution with this entity and compare them to age-matched controls with purely invasive ductal carcinoma IDC and historical data from patients with purely lobular carcinoma and also stain-available tumor specimens for E-cadherin. We have obtained 100 cases of ductal and 50 cases of mixed ductal lobular breast carcinoma. Results Clinically the behavior of mixed ductal lobular tumors seemed to demonstrate some important differences from their ductal counterparts particularly a lower rate of metastatic spread but with a much higher rate of second primary breast cancers. Conclusions Our data suggests that mixed ductal lobular carcinomas are a distinct clinicopathologic entity incorporating some features of both lobular and ductal carcinomas and representing a pleomorphic variant of IDC. Background Infiltrating ductal carcinoma is the most common type of invasive breast cancer accounting for 65 to 80 of invasive breast lesions 1 2 . Its characteristics have been well described including average age of onset its rate of hormone receptor and erbB2 positivity frequency of nodal involvement rates of metastatic spread and overall sur-vival 3 . Historically invasive lobular carcinomas ILC represented the second most common subtype of mammary neoplasia accounting for