Đang chuẩn bị liên kết để tải về tài liệu:
Báo cáo khoa học: "Association between intratumoral lymphatic microvessel density (LMVD) and clinicopathologic features in endometrial cancer: a retrospective cohort study"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Association between intratumoral lymphatic microvessel density (LMVD) and clinicopathologic features in endometrial cancer: a retrospective cohort study | Kawamura et al. World Journal of Surgical Oncology 2010 8 89 http www.wjso.eom content 8 1 89 WORLD JOURNAL OF SURGICAL ONCOLOGY RESEARCH Open Access Association between intratumoral lymphatic microvessel density LMVD and clinicopathologic features in endometrial cancer a retrospective cohort study 1 2 23 4 Lecy Kawamura Filomena M Carvalho Bernardo GL Alves Carlos E Bacchi Joao Carlos Sampaio Goes Marcelo Alvarenga Calil4 Edmund C Baracat1 Jesus P Carvalho1 Abstract Background Lymph node metastasis in endometrial cancer significantly decreases survival rate. Few data on the influence of intratumoral lymphatic microvessel density LMVD on survival in endometrial cancer are available. Our aim was to assess the intratumoral LMVD of endometrial carcinomas and to investigate its association with classical pathological factors lymph node metastasis and survival. Methods Fifty-seven patients with endometrial carcinoma diagnosed between 2000 and 2008 underwent complete surgical staging and evaluation of intratumoral LMVD and other histologic variables. Lymphatic microvessels were identified by immunohistochemical staining using monoclonal antibody against human podoplanin clone D2-40 and evaluated by counting the number of immunostained lymphatic vessels in 10 hot spot areas at 400X magnification. The LMVD was expressed by the mean number of vessels in these 10 hot spot microscopic fields. We next investigated the association of LMVD with the clinicopathologic findings and prognosis. Results The mean number of lymphatic vessels counted in all cases ranged between 0 and 4.7. The median value of mean LMVD was 0.5 and defined the cut-off for low and high LMVD. We identified low intratumoral LMVD in 27 47.4 patients and high LMVD in 30 52.6 patients. High intratumoral LMVD was associated with lesser miometrial and adnaexal infiltration lesser cervical and peritoneal involvement and fewer fatal cases. Although there was lower lymph node involvement among cases with high LMVD .