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Báo cáo khoa học: "Leiomyosarcoma of intravascular origin - a rare tumor entity: clinical pathological study of twelve cases"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Leiomyosarcoma of intravascular origin - a rare tumor entity: clinical pathological study of twelve cases | Tilkorn et al. World Journal of Surgical Oncology 2010 8 103 http www.wjso.eom content 8 1 103 WORLD JOURNAL OF SURGICAL ONCOLOGY RESEARCH Open Access Leiomyosarcoma of intravascular origin -a rare tumor entity clinical pathological study of twelve cases 1 1 11 2 1 3 Daniel J Tilkorn Joerg Hauser Andrej Ring Ole Goertz Ingo Stricker Hans U Steinau Cornelius Kuhnen Abstract Background Leiomysarcoma of intravascular origin is an exceedingly rare entity of malignant soft tissue tumors. They are most frequently encountered in the retroperitoneum arising from the inferior vena cava and are scarcely found to arise from vessels of the extremities. These tumors were analysed with particular reference to treatment outcome and prognosis. The aim of this article is to broaden the knowledge of the clinical course of this rare malignancy. Method During 2000 and 2009 twelve patients were identified with an intravascular origin of a leiomyosarcoma. Details regarding the clinical course follow-up and outcome were assessed with focus on patient survival tumor relapse and metastases and treatment outcome. 3 year survival probability was calculated using Kaplan-Meier method. Results Vascular leiomyosarcomas accounted for 0.7 of all malignant soft tissue tumors treated at our soft tissue sarcoma reference center. The mean follow up period was 38 months. Tumor relapse was encountered in six patients. 6 patients developed metastatic disease. The three year survival was 57 . Conclusion Vascular leiomysarcoma is a rare but aggressive tumor entity with a high rate of local recurrence and metastasis. Background Malignant soft tissue tumors account for 1 of malignant tumors in adults 1 Leiomyosarcomas make up only 5 of these rare soft tissue tumors 2 . Intraabdominal retroperitoneal cutaneous subcutaneous and vascular growth patterns can be distinguished. Vascular leiomyosarcoma arises from major blood vessels and originates directly from the muscular wall of these vessels. Up to 75 3 arise