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Báo cáo khoa học: "Pancreatic insulinoma co-existing with gastric GIST in the absence of neurofibromatosis-1"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Pancreatic insulinoma co-existing with gastric GIST in the absence of neurofibromatosis-1 | BioMed Central World Journal of Surgical Oncology Open Access Case report Pancreatic insulinoma co-existing with gastric GIST in the absence of neurofibromatosis-1 Edward Alabraba1 Simon Bramhall1 Brendan O Sullivan1 Brinder Mahon2 and Philippe Taniere 1 Address University of Birmingham and UHB Foundation NHS Trust Birmingham UK and 2UHB Foundation NHS Trust Birmingham UK Email Edward Alabraba - e.b.alabraba@bham.ac.uk Simon Bramhall - Simon.Bramhall@uhb.nhs.uk Brendan O Sullivan - brendan_o@hotmail.com Brinder Mahon - Brinder.Mahon@uhb.nhs.uk Philippe Taniere - tanierpp@adf.bham.ac.uk Corresponding author Published 13 February 2009 Received 4 November 2008 World Journal of Surgical Oncology 2009 7 18 doi l0.ll86 l477-78l 9-7-18 Accepted 13 February 2009 This article is available from http www.wjso.cOm content 7 l l8 2009 Alabraba et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Gastrointestinal stromal tumours GIST frequently occur in patients with neurofibromatosis type l NF-l . It has been reported that GIST may co-exist with pancreatic endocrine tumors but this has only been in association with NF-l. Case presentation A 76 year old woman presented with a l2 month history of hypoglycaemia symptoms. Abdominal CT scan demonstrated a l3 mm insulinoma localized in the tail of her pancreas. She was commenced on diazoxide and later underwent surgery for enucleation of insulinoma when a small l cm incidental tumour was discovered on her stomach wall which was identified as GIST. Conclusion This is the first case report of a pancreatic insulinoma co-existing with a GIST in a patient without NF-l. In addition we make the first .