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Báo cáo khoa học: "Gastric cancer: predictors of recurrence when lymph-node dissection is inadequate"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Gastric cancer: predictors of recurrence when lymph-node dissection is inadequate | World Journal of Surgical Oncology BioMed Central Open Access Gastric cancer predictors of recurrence when lymph-node dissection is inadequate Esther Una Address Medical Oncology Service Clinical University Hospital Valladolid Spain Email Esther Una - aunacid@hotmail.com Published 17 September 2009 Received 26 June 2009 __ -mno i. a J.i.in IIOÍ n m 7010 7 zo Accepted 17 September 2009 World Journal of Surgical Oncology 2009 7 69 doi l0.ll86 l477-78l 9-7-69 This article is available from http www.wjso.eom content 7 l 69 2009 Una licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background The TNM classification sixth edition requires at least l5 lymph nodes to be examined to allow an accurate staging. However in our environment only 20 of patients have the recommended minimum of l5 nodes removed. Purpose To evaluate clinicopathological predictors of recurrence in patients with gastric cancer undergoing radical resection with an inadequate number of lymph nodes examined. Methods l0l patients were included in this retrospective cohort. We evaluated age gender tumoral location Borrmann type Lauren histotype type of gastrectomy grade invasion depth of tumor lymph node involvement ratio between metastatic and total number of excised lymph nodes keeping 20 as the cutoff value LNR and adjuvant treatment. The association between these variables and recurrence was investigated by using univariate methods and multivariate logistic regression analysis. Results Median range age was 63 years 44-85 . 63 males 37 females. Median follow-up time for the whole patients population was 36 months l0-l04 . Median number of lymph nodes retrieved was 6 0-l4 . Recurrence 50 of l0l cases 49 6 4l hematogeneus dissemination 9 locoregional .