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Báo cáo y học: "CXCR3/CXCL10 expression in the synovium of children with juvenile idiopathic arthritis"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài:CXCR3/CXCL10 expression in the synovium of children with juvenile idiopathic arthritis. | Available online http arthritis-research.eom content 7 2 R241 Research article CXCR3 CXCL10 expression in the synovium of children with juvenile idiopathic arthritis Georgia Martini1 Francesco Zulian1 Fiorella Calabrese2 Marta Bortoli3 Monica Facco3 Anna Cabrelle3 Marialuisa Valente2 Franco Zacchello1 and Carlo Agostini3 Department of Paediatrics Padua University School of Medicine Italy 2Pathology Institute Padua University School of Medicine Italy 3Department of Clinical and Experimental Medicine Padua University School of Medicine Italy Corresponding author Georgia Martini martini@pediatria.unipd.it Received 14 Apr 2004 Revisions requested 26 May 2004 Revisions received 16 Nov 2004 Accepted 22 Nov 2004 Published 7 Jan 2005 Arthritis Res Ther 2005 7 R241-R249 DOI 10.1186 ar1481 2005 Martini et al. licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is cited. Open Access Abstract The accumulation of T cells in the synovial membrane is the crucial step in the pathophysiology of the inflammatory processes characterizing juvenile idiopathic arthritis JIA . In this study we evaluated the expression and the pathogenetic role in oligoarticular JIA of a CXC chemokine involved in the directional migration of activated T cells i.e. IFNy-inducible protein 10 CXCL10 and its receptor CXCR3. Immunochemistry with an antihuman CXCL10 showed that synovial macrophages epithelial cells and endothelial cells bear the chemokine. By flow cytometry and immunochemistry it has been shown that CXCR3 is expressed at high density by virtually all T lymphocytes isolated from synovial fluid SF and infiltrating the synovial membrane. Particularly strongly stained CXCR3 T cells can be observed close to the luminal space and in the perivascular area. Furthermore densitometric