Đang chuẩn bị liên kết để tải về tài liệu:
Báo cáo y học: "Phenotypic and functional characterisation of CD4+ memory T cells homing to the joints in juvenile idiopathic arthritis"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài:Phenotypic and functional characterisation of CD4+ memory T cells homing to the joints in juvenile idiopathic arthritis. | Available online http arthritis-research.eom content 7 2 R256 Research article Phenotypic and functional characterisation of CCR7 and CCR7-CD4 memory T cells homing to the joints in juvenile idiopathic arthritis Marco Gattorno1 Ignazia Prigione2 Fabio Morandi2 Andrea Gregorio1 Sabrina Chiesa2 Francesca Ferlito1 Anna Favre3 Antonio Uccelli4 Claudio Gambini5 Alberto Martini1 and Vito Pistoia2 Open Access 1II Division of Pediatrics University of Genoa Genoa Italy 2Laboratory of Oncology G. Gaslini Institute for Children Genoa Italy 3Department of Surgery G. Gaslini Institute for Children Genoa Italy 4Neuroimmunology Unit Department of Neurosciences Ophthalmology and Genetics and Centre of Excellence for Biomedical Research University of Genoa Genoa Italy 5Department of Pathology G. Gaslini Institute for Children Genoa Italy Contributed equally Corresponding author Marco Gattorno marcogattorno@ospedale-gaslini.ge.it Received 28 Sep 2004 Revisions requested 18 Oct 2004 Revisions received 1 6 Nov 2004 Accepted 29 Nov 2004 Published 1 2 Jan 2005 Arthritis Res Ther 2004 7 R256-R267 DOI 10.1186 ar1485 2005 Gattorno et al. licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract The aim of the study was to characterise CCR7 and CCR7 memory T cells infiltrating the inflamed joints of patients with juvenile idiopathic arthritis JIA and to investigate the functional and anatomical heterogeneity of these cell subsets in relation to the expression of the inflammatory chemokine receptors CXCR3 and CCR5. Memory T cells freshly isolated from the peripheral blood and synovial fluid SF of 25 patients with JIA were tested for the expression of CCR7 CCR5 CXCR3 and interferon-Y by flow cytometry. The chemotactic activity of CD4 SF memory T cells