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Báo cáo y học: "Multilevel examination of minor salivary gland biopsy for Sjögren's syndrome significantly improves diagnostic performance of AECG classification criteria"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài:Multilevel examination of minor salivary gland biopsy for Sjögren's syndrome significantly improves diagnostic performance of AECG classification criteria. | Available online http arthritis-research.eom content 7 2 R343 Research article Multilevel examination of minor salivary gland biopsy for Sjogren s syndrome significantly improves diagnostic performance of AECG classification criteria Patrizia Morbini1 Antonio Manzo2 Roberto Caporali2 Oscar Epis2 Chiara Villa1 Carmine Tinelli3 Enrico Solcia1 and Carlomaurizio Montecucco2 Open Access Department of Pathology IRCCS Policlinico S Matteo Pavia Italy 2Department of Rheumatology IRCCS Policlinico S Matteo Pavia Italy 3Biometric Unit IRCCS Policlinico S Matteo Pavia Italy Corresponding author Patrizia Morbini p.morbini@smatteo.pv.it Received 23 Jun 2004 Revisions requested 4 Oct 2004 Revisions received 15 Nov 2004 Accepted 1 Dec 2004 Published 17 Jan 2005 Arthritis Res Ther 2005 7 R343-R348 DOI 10.1186 ar1486 2005 Morbini et al. licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is cited. Abstract The recently observed low reproducibility of focus score FS assessment at different section depths in a series of single minor salivary gland biopsies highlighted the need for a standardized protocol of extensive histopathological examination of such biopsies in Sjogren s syndrome. For this purpose a cumulative focus score cFS was evaluated on three slides cut at 200-pm intervals from each of a series of 1 20 salivary biopsies. The cFS was substituted for the baseline FS in the American-European Consensus Group AECG criteria set for Sjogren s syndrome classification and then test specificity and sensitivity were assessed against clinical patient re evaluation. Test performances of the AECG classification with the original FS and the score obtained after multilevel examination were statistically compared using receiver operating characteristic ROC curve .