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Báo cáo y học: "High-resolution optical coherence tomographic imaging of osteoarthritic cartilage during open knee surgery"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: High-resolution optical coherence tomographic imaging of osteoarthritic cartilage during open knee surgery. | Available online http arthritis-research.eom content 7 2 R318 Research article High-resolution optical coherence tomographic imaging of osteoarthritic cartilage during open knee surgery Xingde Li1 Scott Martin2 3 Costas Pitris1 Ravi Ghanta1 Debra L Stamper2 3 Michelle Harman2 James G Fujimoto1 and Mark E Brezinski2 3 Massachusetts Institute of Technology Department of Electrical Engineering and Computer Science Research Laboratory of Electronics Cambridge MA USA 2Division of Orthopedic Surgery Brigham and Women s Hospital Harvard Medical School Boston MA USA 3Harvard Medical School Harvard University Longwood Avenue Boston MA USA Corresponding author Mark E Brezinski mebrezin@mit.edu Received 29 Dec 2003 Revisions requested 6 Feb 2004 Revisions received 30 Nov 2004 Accepted 8 Dec 2004 Published 1 7 Jan 2005 Arthritis Res Ther 2005 7 R318-R323 DOI 10.1186 ar1491 2005 Li et al. licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is cited. Open Access Abstract This study demonstrates the first real-time imaging in vivo of human cartilage in normal and osteoarthritic knee joints at a resolution of micrometers using optical coherence tomography OCT . This recently developed high-resolution imaging technology is analogous to B-mode ultrasound except that it uses infrared light rather than sound. Real-time imaging with 11pm resolution at four frames per second was performed on six patients using a portable OCT system with a handheld imaging probe during open knee surgery. Tissue registration was achieved by marking sites before imaging and then histologic processing was performed. Structural changes including cartilage thinning fissures and fibrillations were observed at a resolution substantially higher than is achieved with any current clinical .