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Báo cáo y học: "Is closer linkage between systemic lupus erythematosus and anti-double-stranded DNA antibodies a desirable and attainable goal"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài:Is closer linkage between systemic lupus erythematosus and anti-double-stranded DNA antibodies a desirable and attainable goal? | Available online http arthritis-research.eom content 7 2 85 Commentary Is closer linkage between systemic lupus erythematosus and anti-double-stranded DNA antibodies a desirable and attainable goal Hans C Nossent1 2 and Ole Petter Rekvig2 3 Department of Rheumatology Institute of Clinical Medicine University of Tromso Norway 2Department of Rheumatology University Hospital North Norway Tromso Norway 3Department of Biochemistry Institute of Medical Biology University of Tromso Norway Corresponding author Hans C Nossent hans.nossent@unn.no Published 10 February 2005 Arthritis Res Ther 2005 7 85-87 DOI 10.1186 ar1707 2005 BioMed Central Ltd Abstract The anti-double-stranded DNA anti-dsDNA antibody test incorporated in the 1982 revised American College of Rheumatology criteria for the classification of systemic lupus erythematosus needs updating to reflect current insights and technical achievements including allowance for the presence of nonpathogenic anti-dsDNA antibodies. As we need to develop at least some measure of pathogenicity of anti-dsDNA antibodies we propose that initial anti-dsDNA antibody screening is done by sensitive ELISA and supplemented by more stringent assays. Simultaneously the relevance of anti-dsDNA antibody presence needs to be restricted to clinical manifestations thought to be caused by anti-dsDNA antibody and within an appropriate time frame. Introduction After descriptions of organ involvement in patients with archetypal lupus erythematosus skin lesions and development of the concept of systemic lupus erythematosus SLE as a collagen vascular disease 1 2 a collaborative effort in the USA developed preliminary SLE classification criteria for interseries and epidemiologic evaluation. Retrospectively the cumulative presence of four or more criteria over a 7-year period correctly classified patients with 88 sensitivity and 95 specificity 3 . In 1982 the earlier autoimmune features lupus erythematosus cells or false positive test for syphilis were