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Báo cáo y học: "Biomarkers of endothelial dysfunction, cardiovascular risk factors and atherosclerosis in rheumatoid arthritis"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Biomarkers of endothelial dysfunction, cardiovascular risk factors and atherosclerosis in rheumatoid arthritis. | Available online http arthritis-research.eom content 7 3 R634 Open Access Research article Biomarkers of endothelial dysfunction cardiovascular risk factors and atherosclerosis in rheumatoid arthritis Patrick H Dessein1 Barry I Joffe2 and Sham Singh3 Department of Rheumatology Johannesburg Hospital and Milpark Hospital Parktown University of the Witwatersrand Johannesburg South Africa 2Centre for Diabetes and Endocrinology Houghton University of the Witwatersrand Johannesburg South Africa 3Lancet Laboratories Richmond Johannesburg South Africa Corresponding author Patrick H Dessein Dessein@lancet.co.za Received 9 Jan 2005 Revisions requested 24 Jan 2005 Revisions received 2 Feb 2005 Accepted 15 Feb 2005 Published 24 Mar 2005 Arthritis Research Therapy 2005 7 R634-R643 DOI 10.11 86 ar1 717 This article is online at http arthritis-research.com content 7 3 R634 2005 Dessein et al. licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Cardiovascular event rates are markedly increased in rheumatoid arthritis RA and RA atherogenesis remains poorly understood. The relative contributions of traditional and nontraditional risk factors to cardiovascular disease in RA await elucidation. The present study comprises three components. First we compared biomarkers of endothelial dysfunction vascular cell adhesion molecule VCAM -1 intercellular adhesion molecule ICAM -1 and endothelial leucocyte adhesion molecule ELAM -1 in 74 RA patients and 80 healthy control individuals before and after controlling for traditional and nontraditional cardiovascular risk factors including high-sensitivity C-reactive protein hs-CRP IL-1 IL-6 and tumor necrosis factor-a. Second we investigated the potential role of an extensive range of patient .