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Báo cáo y học: "Gastrin-releasing peptide, substance P and cytokines in rheumatoid arthritis Paul G Green"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Gastrin-releasing peptide, substance P and cytokines in rheumatoid arthritis Paul G Green. | Available online http arthritis-research.eom contents 7 3 111 Commentary Gastrin-releasing peptide substance P and cytokines in rheumatoid arthritis Paul G Green Department of Oral and Maxillofacial Surgery University of California San Francisco San Francisco CA USA Corresponding author Paul G Green paul@itsa.ucsf.edu Published 30 March 2005 This article is online at http arthritis-research.com content 7 3 111 2005 BioMed Central Ltd Arthritis Research Therapy 2005 7 111-113 DOI 10.1186 ar1746 See related research by Grimsholm et al. http arthritis-research.com content 7 3 R416 Abstract Many studies have shown that modulation of cytokine function is effective in ameliorating symptoms of rheumatoid arthritis. Neuropeptides have recently been shown to have powerful effects on the production and release of cytokines and have also been shown to exert potent proinflammatory and anti-inflammatory effects in animal models of inflammatory diseases. An analysis of cytokine and neuropeptide content of synovial fluid from patients with rheumatoid arthritis has revealed a significant correlation between two neuropeptides bombesin gastrin-releasing peptide and substance P and the proinflammatory cytokine interleukin-6 as well as the erythrocyte sedimentation rate. These findings provide further evidence for a role of neuropeptides and cytokines in the pathophysiology of rheumatoid arthritis as well as suggesting additional approaches for the development of novel therapeutic interventions. A lack of a comprehensive understanding of the pathogenesis of rheumatoid arthritis RA has hampered the development of novel therapeutic approaches to the treatment of this disease. In the current issue of this journal Grimsholm and colleagues 1 have investigated a role for neuropeptides in the pathology of RA. Although many different cell types such as macrophages and synoviocytes have long been known to be involved in RA it has recently been realized that the peripheral nervous system has a