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Báo cáo y học: "Hypothalamic-pituitary-adrenal stress axis function and the relationship with chronic widespread pain and its antecedent"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Hypothalamic-pituitary-adrenal stress axis function and the relationship with chronic widespread pain and its antecedents. | Available online http arthritis-research.eom content 7 5 R992 Research article Hypothalamic-pituitary-adrenal stress axis function and the relationship with chronic widespread pain and its antecedents John McBeth1 Yee H Chiu2 Alan J Silman1 David Ray3 Richard Morriss4 Chris Dickens5 Anindya Gupta1 and Gary J Macfarlane1 2 1Arthritis Research Campaign ARC Epidemiology Unit School of Epidemiology and Health Sciences University of Manchester Manchester United Kingdom 2Unit of Chronic Disease Epidemiology School of Epidemiology and Health Sciences University of Manchester Manchester United Kingdom 3Endocrine Sciences Research Group University of Manchester Manchester United Kingdom 4University Department of Psychiatry Royal Liverpool University Hospital Liverpool United Kingdom 5Department of Psychiatry University of Manchester United Kingdom Corresponding author John McBeth john.mcbeth@manchester.ac.uk Received 4 Oct 2004 Revisions requested 9 Nov 2004 Revisions received 9 May 2005 Accepted 20 May 2005 Published 1 7 Jun 2005 Arthritis Research Therapy 2005 7 R992-R1000 DOI 10.1186 ar1772 This article is online at http arthritis-research.com content 7 5 R992 2005 McBeth et al. licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Open Access Abstract In clinic studies altered hypothalamic-pituitary-adrenal HPA axis function has been associated with fibromyalgia a syndrome characterised by chronic widespread body pain. These results may be explained by the associated high rates of psychological distress and somatisation. We address the hypothesis that the latter rather than the pain might explain the HPA results. A population study ascertained pain and psychological status in subjects aged 25 to 65 years. Random samples were selected