Đang chuẩn bị liên kết để tải về tài liệu:
Báo cáo y học: "Raloxifene reduces urokinase-type plasminogen activator-dependent proliferation of synoviocytes from patients with rheumatoid arthritis"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Raloxifene reduces urokinase-type plasminogen activator-dependent proliferation of synoviocytes from patients with rheumatoid arthritis. | Available online http arthritis-research.eom content 7 6 R1244 Research article Raloxifene reduces urokinase-type plasminogen activator-dependent proliferation of synoviocytes from patients with rheumatoid arthritis S Guiducci1 A Del Rosso1 M Cinelli1 F Perfetto1 R Livi1 A Rossi5 A Gabrielli3 R Giacomelli4 N Iori5 G Fibbi2 M Del Rosso2 and M Matucci Cerinic1 Open Access Department of Internal Medicine Division of Rheumatology University of Florence Florence Italy department of Experimental Pathology and Oncology University of Florence Florence Italy institute of Clinical Medicine Hematology and Clinical Immunology University of Ancona Didactic pole Torrette di Ancona Ancona Italy department of Internal Medicine and Public Health University of L Aquila L Aquila Italy 5Medical Direction Eli Lilly Italia S.p.a. Sesto Fiorentino FI Italy Corresponding author M Matucci Cerinic cerinic@unifi.it Received 10 Sep 2004 Revisions requested 13 Oct 2004 Revisions received 28 Jul 2005 Accepted 10 Aug 2005 Published 8 Sep 2005 Arthritis Research Therapy 2005 7 R1244-R1 253 DOI 10.1186 ar1815 This article is online at http arthritis-research.com content 7 6 R1244 2005 Guiducci et al. licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Extracellular fibrinolysis controlled by the membrane-bound fibrinolytic system is involved in cartilage damage and rheumatoid arthritis RA synovitis. Estrogen status and metabolism seem to be impaired in RA and synoviocytes show receptors for estrogens. Our aims in this study were to evaluate in healthy and RA synoviocytes the effects of Raloxifene RAL a selective estrogen receptor modulator SERM on proliferation the components of the fibrinolytic system and chemoinvasion. The effects of RAL were .