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Báo cáo y học: " Correction: Tolerability and adverse events in clinical trials of celecoxib in osteoarthritis and rheumatoid arthritis: systematic review and meta-analysis of information from company clinical trial reports"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Correction: Tolerability and adverse events in clinical trials of celecoxib in osteoarthritis and rheumatoid arthritis: systematic review and meta-analysis of information from company clinical trial reports. | Available online http arthritis-research.eom content 8 1 401 Correction Correction Tolerability and adverse events in clinical trials of celecoxib in osteoarthritis and rheumatoid arthritis systematic review and meta-analysis of information from company clinical trial reports R Andrew Moore1 Sheena Derry1 Geoffrey T Makinson2 and Henry J McQuay1 1Pain Research and Nuffield Department of Anaesthetics University of Oxford Oxford Radcliffe NHS Trust Oxford UK 2Department of Outcomes Research and Evidence-based Medicine Pfizer Ltd Walton Oaks Surrey UK Corresponding author R Andrew Moore andrew.moore@pru.ox.ac.uk Published 14 November 2005 Arthritis Research Therapy 2006 8 401 doi 10.1186 ar1866 This article is online at http arthritis-research.com content 8 1 401 2005 BioMed Central Ltd After publication of our recent article 1 we noticed a typographical error in the Results section. The sentence Celecoxib at both licensed and any dose always produced more endoscopic ulcers than NSAID should read Celecoxib at both licensed and any dose always produced fewer endoscopic ulcers than NSAID . The relevant section of our article with corrected text follows below Endoscopically detected ulcers Seven trials were designed to detect the presence of endoscopic ulcers of 3 mm or more in which celecoxib was compared with placebo and or NSAID additional file 4 . Six reported at 12 weeks and one at 24 weeks. Five trials also reported results according to the use of low dose aspirin of 325 mg or less daily. These results are shown in Table 8 and Figure 4 analysed across all patients and according to aspirin use. In no comparison was there any significant difference between celecoxib and placebo. For both celecoxib and NSAID there was the same 6 absolute increase in endoscopic ulcers with aspirin use. Celecoxib at both licensed and any dose always produced fewer endoscopic ulcers than NSAID. The NNTp was the same at 7-8 both with and without concomitant aspirin use. References 1. .