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Báo cáo y học: "No evidence for an association between the -871 T/C promoter polymorphism in the B-cell-activating factor gene and primary Sjögren's syndrome"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: No evidence for an association between the -871 T/C promoter polymorphism in the B-cell-activating factor gene and primary Sjögren's syndrome. | Available online http arthritis-research.eom content 8 1 R30 Research article No evidence for an association between the -871 T C promoter polymorphism in the B-cell-activating factor gene and primary Sjogren s syndrome Jacques-Eric Gottenberg1 Jeremie Sellam1 Marc Ittah1 Frédéric Lavie1 Alexis Proust2 Habib Zouali3 Christelle Sordet4 Jean Sibilia4 Robert P Kimberly5 Xavier Mariette1 and Corinne Miceli-Richard1 Open Access 1 Rhumatologie INSERM E 109 Hôpital Bicêtre Assistance Publique-Hôpitaux de Paris Université Paris-Sud 11 Le Kremlin Bicêtre France 2Hématologie INSERM E 109 Hôpital de Bicêtre Assistance Publique-Hôpitaux de Paris AP-HP Le Kremlin Bicêtre France 3Fondation Jean Dausset Centre d Etude du Polymorphisme Humain CEPH Paris France 4Rhumatologie Centre Hospitalier Universitaire de Strasbourg Strasbourg France 5Division of Clinical Immunology and Rheumatology University of Alabama Birmingham AL USA Contributed equally Corresponding author Xavier Mariette xavier.mariette@bct.ap-hop-paris.fr Received 29 Aug 2005 Revisions requested 5 Oct 2005 Revisions received 25 Oct 2005 Accepted 14 Dec 2005 Published 9 Jan 2006 Arthritis Research Therapy 2006 8 R30 doi 10.1186 ar1 884 This article is online at http arthritis-research.com content 8 1 R30 2006 Gottenberg et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Polyclonal B cell activation might be related to pathogenic overexpression of B-cell-activating factor BAFF in primary Sjogren s syndrome pSS and other autoimmune diseases. We therefore investigated whether BAFF over-expression in pSS could be a primary genetically determined event that leads to the disease. The complete BAFF gene was sequenced in Caucasian pSS patients and control individuals. The .