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Báo cáo y học: "Detailed analysis of the variability of peptidylarginine deiminase type 4 in German patients with rheumatoid arthritis: a case– control study"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Detailed analysis of the variability of peptidylarginine deiminase type 4 in German patients with rheumatoid arthritis: a case– control study. | Available online http arthritis-research.eom content 8 2 R34 Research article Detailed analysis of the variability of peptidylarginine deiminase type 4 in German patients with rheumatoid arthritis a casecontrol study Berthold Hoppe1 Thomas Haupl2 Rudolf Gruber3 Holger Kiesewetter1 Gerd R Burmester2 Abdulgabar Salama1 and Thomas Dorner1 institute of Transfusion Medicine Campus Virchow-Klinikum Charite-Universitatsmedizin Berlin Germany 2Department of Rheumatology and Clinical Immunology Campus Charite Mitte Charite-Universitatsmedizin Berlin Germany 3Out-Patient Clinic for Internal Medicine Ludwig-Maximilians-Universitat Munchen Germany Corresponding author Berthold Hoppe berthold.hoppe@charite.de Received 7 Nov 2005 Revisions requested 24 Nov 2005 Accepted 19 Dec 2005 Published 16 Jan 2006 Arthritis Research Therapy 2006 8 R34 doi 10.1186 ar1 889 This article is online at http arthritis-research.com content 8 2 R34 2006 Hoppe et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Open Access Abstract Peptidylarginine deiminase type 4 PADI4 genotypes were shown to influence susceptibility to rheumatoid arthritis RA in the Japanese population. Such an association could not previously be confirmed in different European populations. In the present study we analysed exons 2-4 of PADI4 in 102 German RA patients and 102 healthy individuals to study the influence of PADI4 variability on RA susceptibility by means of haplotypespecific DNA sequencing. Analyses of the influence of PADI4 and HLA-DRB1 genotypes on disease activity and on levels of anti-cyclic citrullinated peptide antibodies were performed. Comparing the frequencies of PADI4 haplotype 4 padi4_89 G padi4_90 T padi4_92 G padi4_94 T padi4_104 C padi4_95 G padi4_96 T .