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Báo cáo y học: "roteoglycan 4 downregulation in a sheep meniscectomy model of early osteoarthritis"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài:Proteoglycan 4 downregulation in a sheep meniscectomy model of early osteoarthritis. | Available online http arthritis-research.eom content 8 2 R41 Research article Proteoglycan 4 downregulation in a sheep meniscectomy model of early osteoarthritis Allan A Young1 Susan McLennan2 Margaret M Smith1 Susan M Smith1 Martin A Cake3 Richard A Read3 James Melrose1 David H Sonnabend1 Carl R Flannery4 and Christopher B Little1 1 Raymond Purves Research Laboratory Institute of Bone and Joint Research Royal North Shore Hospital University of Sydney Pacific Highway St Leonards NSW 2065 Australia 2Department of Endocrinology Royal Prince Alfred Hospital and Department of Medicine University of Sydney Missenden Road Camperdown NSW 2050 Australia 3School of Veterinary and Biomedical Sciences Murdoch University South Street Murdoch WA 6150 Australia 4Wyeth Research 200 Cambridge Park Drive Cambridge MA 02140 USA Corresponding author Allan A Young al_young@bigpond.com Received 23 Nov 2005 Revisions requested 20 Dec 2005 Revisions received 10 Jan 2006 Accepted 1 2 Jan 2006 Published 31 Jan 2006 Arthritis Research Therapy 2006 8 R41 doi 10.1186 ar1898 This article is online at http arthritis-research.com content 8 2 R41 2006 Young et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Open Access Abstract Osteoarthritis is a disease of multifactorial aetiology characterised by progressive breakdown of articular cartilage. In the early stages of the disease changes become apparent in the superficial zone of articular cartilage including fibrillation and fissuring. Normally a monolayer of lubricating molecules is adsorbed on the surface of cartilage and contributes to the minimal friction and wear properties of synovial joints. Proteoglycan 4 is the lubricating glycoprotein believed to be primarily responsible for this boundary .