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Báo cáo y học: "Vitamin D receptor gene BsmI polymorphisms in Thai patients with systemic lupus erythematosus"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài:Vitamin D receptor gene BsmI polymorphisms in Thai patients with systemic lupus erythematosus. | Available online http arthritis-research.eom content 8 2 R48 Open Access Research article Vitamin D receptor gene BsmI polymorphisms in Thai patients with systemic lupus erythematosus Wilaiporn Sakulpipatsin1 Oravan Verasertniyom2 Kanokrat Nantiruj1 Kitti Totemchokchyakarn1 Porntawee Lertsrisatit1 and Suchela Janwityanujit1 1 Division of Allergy Immunology and Rheumatology Department of Medicine Faculty of Medicine Ramathibodi Hospital Mahidol University Rama 6 Road Bangkok10400 Thailand 2Research Center Department of Medicine Faculty of Medicine Ramathibodi Hospital Mahidol University Rama 6 Road Bangkok 10400 Thailand Corresponding author Suchela Janwityanujit rasjw@mahidol.ac.th Received 15 Sep 2005 Revisions requested 13 Oct 2005 Revisions received 31 Jan 2006 Accepted 31 Jan 2006 Published 20 Feb 2006 Arthritis Research Therapy 2006 8 R48 doi 10.1186 ar1910 This article is online at http arthritis-research.com content 8 2 R48 2006 Sakulpipatsin et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract The immunomodulatory role of 1 25-dihydroxyvitamin D3 is well known. An association between vitamin D receptor VDR gene BsmI polymorphisms and systemic lupus erythematosus SLE has been reported. To examine the characteristics of VDR gene BsmI polymorphisms in patients with SLE and the relationship of polymorphisms to the susceptibility and clinical manifestations of SLE VDR genotypings of 101 Thai patients with SLE and 194 healthy controls were performed based on polymerase chain reaction-restriction fragment length polymorphism PCR-RFLP . The relationship between VDR gene BsmI polymorphisms and clinical manifestations of SLE was evaluated. The distribution of VDR genotyping in patients with SLE was 1.9 for BB .