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Báo cáo y học: "Expression and function of inducible co-stimulator in patients with systemic lupus erythematosus: possible involvement in excessive interferon-γ and anti-double-stranded DNA antibody production"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Expression and function of inducible co-stimulator in patients with systemic lupus erythematosus: possible involvement in excessive interferon-γ and anti-double-stranded DNA antibody production. | Available online http arthritis-research.eom content 8 3 R62 Research article Expression and function of inducible co-stimulator in patients with systemic lupus erythematosus possible involvement in excessive interferon-y and anti-double-stranded DNA antibody production Manabu Kawamoto1 Masayoshi Harigai1 2 Masako Hara1 Yasushi Kawaguchi1 Katsunari Tezuka3 Michi Tanaka1 Tomoko Sugiura1 Yasuhiro Katsumata1 Chikako Fukasawa1 Hisae Ichida1 Satomi Higami1 and Naoyuki Kamatani1 institute of Rheumatology Tokyo Women s Medical University Tokyo Japan 2Clinical Research Center Tokyo Medical and Dental University Tokyo Japan 3Central Pharmaceutical Research Institute Japan Tobacco Inc. Osaka Japan Corresponding author Masayoshi Harigai mharigai.mpha@tmd.ac.jp Received 9 Aug 2005 Revisions requested 7 Sep 2005 Revisions received 1 2 Jan 2006 Accepted 21 Feb 2006 Published 22 Mar 2006 Arthritis Research Therapy 2006 8 R62 doi 10.1186 ar1928 This article is online at http arthritis-research.com content 8 3 R62 2006 Kawamoto et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Open Access Abstract Inducible co-stimulator ICOS is the third member of the CD28 cytotoxic T-lymphocyte associated antigen-4 family and is involved in the proliferation and activation of T cells. A detailed functional analysis of ICOS on peripheral blood T cells from patients with systemic lupus erythematosus SLE has not yet been reported. In the present study we developed a fully human anti-human ICOS mAb JTA009 with high avidity and investigated the immunopathological roles of ICOS in SLE. JTA009 exhibited higher avidity for ICOS than a previously reported mAb namely SA12. Using JTA009 ICOS was detected in a substantial proportion of unstimulated peripheral .