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Báo cáo y học: "Voluntary activation failure is detectable in some myositis patients with persisting quadriceps femoris weakness: an observational study"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Voluntary activation failure is detectable in some myositis patients with persisting quadriceps femoris weakness: an observational study. | Available online http arthritis-research.eom content 8 3 R67 Research article Voluntary activation failure is detectable in some myositis patients with persisting quadriceps femoris weakness an observational study Catherine B Molloy Ahmed O Al-Omar Kathryn T Edge and Robert G Cooper University of Manchester Rheumatic Disease Centre Hope Hospital Eccles Old Road Salford M6 8HD UK Corresponding author Catherine B Molloy catherine_molloy@doctors.net.uk Received 12 Dec 2005 Revisions requested 19 Jan 2006 Revisions received 1 8 Feb 2006 Accepted 14 Mar 2006 Published 1 0 Apr 2006 Arthritis Research Therapy 2006 8 R67 doi 10.1186 ar1 935 This article is online at http arthritis-research.com content 8 3 R67 2006 Molloy et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Open Access Abstract This cross-sectional observational study was undertaken to examine whether voluntary activation failure could contribute to the persisting weakness observed in some patients with treated idiopathic inflammatory myositis. In 20 patients with myositis of more than six months duration 5 males 15 females mean 1 SD age 53 11 years and 102 normal subjects 44 males 58 females mean age 32 8 years isometric maximum voluntary contractions MVCs of the dominant quadriceps femoris QF were quantified. Absolute MVC results of normal subjects and patients were then normalised with respect to lean body mass force per units of lean body mass giving a result in Newtons per kilogram. Based on mass-normalised force data of normal subjects patients were arbitrarily stratified into weak and not weak subgroups. During further MVC attempts the twitch interpolation technique was used to assess whether the QF voluntary activation of patients was complete. This .