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Báo cáo y học: "Differential expression, function and response to inflammatory stimuli of 11β-hydroxysteroid dehydrogenase type 1 in human fibroblasts: a mechanism for tissue-specific regulation of inflammation"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Differential expression, function and response to inflammatory stimuli of 11β-hydroxysteroid dehydrogenase type 1 in human fibroblasts: a mechanism for tissue-specific regulation of inflammation. | Available online http arthritis-research.eom content 8 4 R108 Research article Differential expression function and response to inflammatory stimuli of 11p-hydroxysteroid dehydrogenase type 1 in human fibroblasts a mechanism for tissue-specific regulation of inflammation Rowan S Hardy1 Andrew Filer2 Mark S Cooper1 Greg Parsonage2 Karim Raza2 Debbie L Hardie2 Elizabeth H Rabbitt1 Paul M Stewart1 Christopher D Buckley2 and Martin Hewison3 Open Access Division of Medical Sciences Institute of Biomedical Research The University of Birmingham Medical School Birmingham UK 2Division of Immunity and Infection Institute of Biomedical Research The University of Birmingham Medical School Birmingham UK 3Division of Endocrinology Diabetes and Metabolism Cedars-Sinai Medical Center Los Angeles California USA Corresponding author Martin Hewison martin.hewison@cshs.org Received 7 Apr 2006 Revisions requested 10 May 2006 Revisions received 22 May 2006 Accepted 19 Jun 2006 Published 17 Jul 2006 Arthritis Research Therapy 2006 8 R108 doi 10.1186 ar1993 This article is online at http arthritis-research.com content 8 4 R108 2006 Hardy et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Stromal cells such as fibroblasts play an important role in defining tissue-specific responses during the resolution of inflammation. We hypothesized that this involves tissue-specific regulation of glucocorticoids mediated via differential regulation of the enzyme 11 p-hydroxysteroid dehydrogenase type 1 11 p-HSD1 . Expression activity and function of 11p-HSD1 was assessed in matched fibroblasts derived from various tissues synovium bone marrow and skin obtained from patients with rheumatoid arthritis or osteoarthritis. 11p-HSD1 was expressed in .