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Báo cáo y học: "Analog peptides of type II collagen can suppress arthritis in HLA-DR4"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Analog peptides of type II collagen can suppress arthritis in HLA-DR4 . | Available online http arthritis-research.eom content 8 5 R150 Research article Analog peptides of type II collagen can suppress arthritis in HLA-DR4 DRB1 0401 transgenic mice Yoshihiko Sakurai1 2 David D Brand3 Bo Tang1 Edward F Rosloniec3 John M Stuart3 Andrew H Kang1 3 and Linda K Myers4 Department of Medicine University of Tennessee 956 Court Avenue Memphis TN 38163 USA 2Current address Department of Surgery National Hospital Organization Kanagawa Hospital 666-1 Ochiai Hadano-city Kanagawa 257-8585 Japan 3Research Service Veterans Affairs Medical Center 1 030 Jefferson Ave. Memphis TN 38104 USA department of Pediatrics University of Tennessee 956 Court Avenue Memphis TN 381 63 USA Corresponding author Linda K Myers lmyers@utmem.edu Received 14 Aug 2006 Accepted 18 Sep 2006 Published 18 Sep 2006 Arthritis Research Therapy 2006 8 R150 doi 10.1186 ar2043 This article is online at http arthritis-research.com content 8 5 R150 2006 Sakurai et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Open Access Abstract Rheumatoid arthritis RA is an autoimmune disease associated with the recognition of self proteins secluded in diarthrodial joints. We have previously established that mice transgenic for the human DR genes associated with RA are susceptible to collagen-induced arthritis CIA and we have identified a determinant of type II collagen CII263_270 that triggers T-cell immune responses in these mice. We have also determined that an analog of CII263_270 would suppress disease in DR1 transgenic mice. Because the immunodominant determinant is the same for both DR1 transgenic and DR4 transgenic mice we attempted to determine whether the analog peptide that was suppressive in DR1 transgenic mice would also be effective in .