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Báo cáo khoa học: "Analysis of clinical and dosimetric factors associated with severe acute radiation pneumonitis in patients with locally advanced non-small cell lung cancer treated with concurrent chemotherapy and intensity-modulated radiotherapy"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Radiation Oncology cung cấp cho các bạn kiến thức về ngành y đề tài: Analysis of clinical and dosimetric factors associated with severe acute radiation pneumonitis in patients with locally advanced non-small cell lung cancer treated with concurrent chemotherapy and intensity-modulated radiotherapy. | Shi etal. Radiation Oncology 2010 5 35 http www.ro-journal.eom content 5 1 35 RADIATION ONCOLOGY RESEARCH Open Access Analysis of clinical and dosimetric factors associated with severe acute radiation pneumonitis in patients with locally advanced non-small cell lung cancer treated with concurrent chemotherapy and intensity-modulated radiotherapy Anhui Shi Guangying Zhu Hao Wu Rong Yu Fuhai Li and Bo Xu Abstract Background To evaluate the association between the clinical dosimetric factors and severe acute radiation pneumonitis SARP in patients with locally advanced non-small cell lung cancer LANSCLC treated with concurrent chemotherapy and intensity-modulated radiotherapy IMRT . Methods We analyzed 94 LANSCLC patients treated with concurrent chemotherapy and IMRT between May 2005 and September 2006. SARP was defined as greater than or equal 3 side effects and graded according to Common Terminology Criteria for Adverse Events CTCAE version 3.0. The clinical and dosimetric factors were analyzed. Univariate and multivariate logistic regression analyses were performed to evaluate the relationship between clinical dosimetric factors and SARP Results Median follow-up was 10.5 months range 6.5-24 . Of 94 patients 11 11.7 developed SARP. Univariate analyses showed that the normal tissue complication probability NTCP mean lung dose MLD relative volumes of lung receiving more than a threshold dose of 5-60 Gy at increments of 5 Gy V5-V60 chronic obstructive pulmonary disease COPD and Forced Expiratory Volume in the first second FEV1 were associated with SARP p 0.05 . In multivariate analysis NTCP value p 0.001 and V10 p 0.015 were the most significant factors associated with SARP. The incidences of SARP in the group with NTCP 4.2 and NTCP 4.2 were 43.5 and 1.4 respectively p 0.01 . The incidences of SARP in the group with V10 50 and V10 50 were 5.7 and 29.2 respectively p 0.01 . Conclusions NTCP value and V10 are the useful indicators for predicting SARP in NSCLC patients .