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Báo cáo khoa học: "Quality of life and tumor control after short split-course chemoradiation for anal canal carcinoma"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Radiation Oncology cung cấp cho các bạn kiến thức về ngành y đề tài: Quality of life and tumor control after short split-course chemoradiation for anal canal carcinoma. | Provencher et al. Radiation Oncology 2010 5 41 http www.ro-journal.eom content 5 1 41 RADIATION ONCOLOGY RESEARCH Open Access Quality of life and tumor control after short split-course chemoradiation for anal canal carcinoma Sawyna Provencher 21 2 Christoph Oehler 23 Sophie Lavertu 1 2 Marjory Jolicoeur1 Bernard Fortin1 and David Donath1 Abstract Purpose To evaluate quality of life QOL and outcome of patients with anal carcinoma treated with short split-course chemoradiation CRT . Methods From 1991 to 2005 58 patients with anal cancer were curatively treated with CRT. External beam radiotherapy 52 Gy 26 fractions with elective groin irradiation 24 Gy was applied in 2 series divided by a median gap of 12 days. Chemotherapy including fluorouracil and Mitomycin-C was delivered in two sequences. Long-term QOL was assessed using the site-specific EORTC QLQ-CR29 and the global QLQ-C30 questionnaires. Results Five-year local control colostomy-free survival and overall survival were 78 94 and 80 respectively. The global QOL score according to the QLQ-C30 was good with 70 out of 100. The QLQ-CR29 questionnaire revealed that 77 of patients were mostly satisfied with their body image. Significant anal pain or fecal incontinence was infrequently reported. Skin toxicity grade 3 or 4 was present in 76 of patients and erectile dysfunction was reported in 100 of male patients. Conclusions Short split-course CRT for anal carcinoma seems to be associated with good local control survival and long-term global QOL. However it is also associated with severe acute skin toxicity and sexual dysfunction. Implementation of modern techniques such as intensity-modulated radiation therapy IMRT might be considered to reduce toxicity. Introduction Sphincter-sparing chemoradiation CRT has evolved as the standard of care for most patients with squamous cell carcinoma of the anal canal. Combined CRT was first introduced by Nigro et al. in the mid-1970s and has resulted in improved local and regional