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Báo cáo khoa học: " Role of p53 mutation in the effect of boron neutron capture therapy on oral squamous cell carcinoma"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Radiation Oncology cung cấp cho các bạn kiến thức về ngành y đề tài: " Role of p53 mutation in the effect of boron neutron capture therapy on oral squamous cell carcinoma. | Radiation Oncology BioMed Central Open Access Role of p53 mutation in the effect of boron neutron capture therapy on oral squamous cell carcinoma Yusei Fujita1 Itsuro Kato1 Soichi Iwai1 Koji Ono2 Minoru Suzuki2 Yoshinori Sakurai2 Ken Ohnishi3 Takeo Ohnishi3 and Yoshiaki Yura 1 Address Department of Oral and Maxillofacial Surgery Osaka University Graduate School of Dentistry Osaka Japan 2Particle Radiation Oncology Research Center Laboratory Research Reactor Institute Kyoto University Osaka Japan and 3Department of Biology School of Medicine Nara Medical University Nara Japan Email Yusei Fujita - fujisan@dent.osaka-u.ac.jp Itsuro Kato - katoitsu@dent.osaka-u.ac.jp Soichi Iwai - s-iwai@dent.osaka-u.ac.jp Koji Ono - onokoji@rri.kyoto-u.ac.jp Minoru Suzuki - msuzuki@rri.kyoto-u.ac.jp Yoshinori Sakurai - ysakurai@rri.kyoto-u.ac.jp Ken Ohnishi - Kohnishi@naramed-u.ac.jp Takeo Ohnishi - Tohnishi@naramed-u.ac.jp Yoshiaki Yura - yura@dent.osaka-u.ac.jp Corresponding author Published II December 2009 Received 3 September 2009 Accepted 1 1 December 2009 Radiation Oncology 2009 4 63 doi 10.1186 1748-717X-4-63 This article is available from http www.ro-journal.cOm content 4 1 63 2009 Fujita et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Boron neutron capture therapy BNCT is a selective radiotherapy being effective for the treatment of even advanced malignancies in head and neck regions as well as brain tumors and skin melanomas. To clarify the role of p53 gene the effect of BNCT on oral squamous cell carcinoma SCC cells showing either wild- SAS neo or mutant-type SAS mp53 p53 was examined. Methods Cells were exposed to neutron beams in the presence of boronophenylalanine BPA at Kyoto University Research .