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Fibroblast-like synovial cells from normal and inflamed knee joints differently affect the expression of pain-related receptors in sensory neurones: a co-culture study

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Fibroblast-like synovial cells from normal and inflamed knee joints differently affect the expression of pain-related receptors in sensory neurones: a co-culture study Gisela Segond von Banchet1, Jonny Richter1, Marion Hückel2,3, Christina Rose3, Rolf Bräuer3 and Hans-Georg Schaible1 1Institute 2Current of Physiology, University of Jena, Teichgraben 8, D-07740 Jena, Germany address: Roche Diagnostics GmbH, D-82377 Penzberg, Germany 3Institute of Pathology, University of Jena, Ziegelmühlenweg, D-07740 Jena, Germany Corresponding author: Hans-Georg Schaible, Hans-Georg.Schaible@mti.uni-jena.de Received: 31 Aug 2006 Revisions requested: 3 Oct 2006 Revisions received: 20 Dec 2006 Accepted: 25 Jan 2007 Published: 25 Jan 2007 Arthritis Research & Therapy 2007, 9:R6 (doi:10.1186/ar2112) This article is. | Available online http arthritis-research.eom content 9 1 R6 Research article Fibroblast-like synovial cells from normal and inflamed knee joints differently affect the expression of pain-related receptors in Sensory neurones a co-culture study Gisela Segond von Banchet1 Jonny Richter1 Marion Huckel2 3 Christina Rose3 Rolf Brauer3 and Hans-Georg Schaible1 institute of Physiology University of Jena Teichgraben 8 D-07740 Jena Germany 2Current address Roche Diagnostics GmbH D-82377 Penzberg Germany institute of Pathology University of Jena Ziegelmuhlenweg D-07740 Jena Germany Corresponding author Hans-Georg Schaible Hans-Georg.Schaible@mti.uni-jena.de Received 31 Aug 2006 Revisions requested 3 Oct 2006 Revisions received 20 Dec 2006 Accepted 25 Jan 2007 Published 25 Jan 2007 Arthritis Research Therapy 2007 9 R6 doi 10.1186 ar2112 This article is online at http arthritis-research.com content 9 1 R6 2007 Segond von Banchet et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Open Access Abstract Innervation of the joint with thinly myelinated and unmyelinated sensory nerve fibres is crucial for the occurrence of joint pain. During inflammation in the joint sensory fibres show changes in the expression of receptors that are important for the activation and sensitization of the neurones and the generation of joint pain. We recently reported that both neurokinin 1 receptors and bradykinin 2 receptors are upregulated in dorsal root ganglion DRG neurones the cell bodies of sensory fibres in the course of acute and chronic antigen-induced arthritis in the rat. In this study we begin to address mechanisms of the interaction between fibroblast-like synovial FLS cells and sensory neurones by establishing a co-culture system of FLS cells