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Báo cáo y học: "Vaccination response to tetanus toxoid and 23-valent pneumococcal vaccines following administration of a single dose of abatacept: a randomized, open-label, parallel group study in healthy subjects"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Vaccination response to tetanus toxoid and 23-valent pneumococcal vaccines following administration of a single dose of abatacept: a randomized, open-label, parallel group study in healthy subjects. | Available online http arthritis-research.eom content 9 2 R38 Research article Vaccination response to tetanus toxoid and 23-valent pneumococcal vaccines following administration of a single dose of abatacept a randomized open-label parallel group study in healthy subjects Lee Tay1 Francisco Leon2 George Vratsanos3 Ralph Raymond4 and Michael Corbo3 Clinical Discovery Bristol-Myers Squibb PO Box 4000 Princeton NJ 08543-4000 USA 2Clinical Development Inflammatory Diseases Medlmmune 1 Medlmmune Way Gaithersburg MD 20878 USA 3Global Clinical Research Immunology PO Box 4000 Bristol-Myers Squibb Princeton NJ 08543-4000 USA 4Global Biometric Sciences PO Box 4000 Bristol-Myers Squibb Princeton NJ 08543-4000 USA Corresponding author Lee Tay lee.tay@bms.com Received 31 Jul 2006 Revisions requested 31 Aug 2006 Revisions received 26 Mar 2007 Accepted 10 Apr 2007 Published 10 Apr 2007 Arthritis Research Therapy 2007 9 R38 doi 10.1186 ar2174 This article is online at http arthritis-research.com content 9 2 R38 2007 Tay et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Open Access Abstract The effect of abatacept a selective T-cell eo-stimulation modulator on vaccination has not been previously investigated. In this open-label single-dose randomized parallel-group controlled study the effect of a single 750 mg infusion of abatacept on the antibody response to the intramuscular tetanus toxoid vaccine primarily a memory response to a T-cell-dependent peptide antigen and the intramuscular 23-valent pneumococcal vaccine a less T-cell-dependent response to a polysaccharide antigen was measured in 80 normal healthy volunteers. Subjects were uniformly randomized to receive one of four treatments Group A control group subjects received .