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Báo cáo y học: "Proton-pump inhibitors are associated with a reduced risk for bleeding and perforated gastroduodenal ulcers attributable to non-steroidal anti-inflammatory drugs: a nested case-control study"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Proton-pump inhibitors are associated with a reduced risk for bleeding and perforated gastroduodenal ulcers attributable to non-steroidal anti-inflammatory drugs: a nested case-control study. | Available online http arthritis-research.eom content 9 3 R52 Research article Proton-pump inhibitors are associated with a reduced risk for bleeding and perforated gastroduodenal ulcers attributable to non-steroidal anti-inflammatory drugs a nested case-control study Harald E Vonkeman1 Robert W Fernandes2 Job van der Palen3 Eric N van Roon4 and Mart AFJ van de Laar1 1 Department of Rheumatology and Clinical Immunology Medisch Spectrum Twente Hospital and University of Twente Ariensplein 1 7500 KA Enschede The Netherlands 2Stroinkslanden Pharmacy Veldhoflanden 90 7542 LX Enschede The Netherlands department of Clinical Epidemiology and Statistics Medisch Spectrum Twente Hospital Haaksbergerstraat 55 7500 KA Enschede The Netherlands department of Clinical Pharmacy and Clinical Pharmacology Medisch Centrum Leeuwarden Henri Dunantweg 2 8934 AD Leeuwarden The Netherlands Corresponding author Harald E Vonkeman h.vonkeman@ziekenhuis-mst.nl Received 11 Feb 2007 Revisions requested 16 Apr 2007 Revisions received 28 Apr 2007 Accepted 23 May 2007 Published 23 May 2007 Arthritis Research Therapy 2007 9 R52 doi 10.1186 ar2207 This article is online at http arthritis-research.com content 9 3 R52 2007 Vonkeman et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Open Access Abstract Treatment with non-steroidal anti-inflammatory drugs NSAIDs is hampered by gastrointestinal ulcer complications such as ulcer bleeding and perforation. The efficacy of proton-pump inhibitors in the primary prevention of ulcer complications arising from the use of NSAIDs remains unproven. Selective cyclooxygenase-2 COX-2 inhibitors reduce the risk for ulcer complications but not completely in high-risk patients. This study determines which patients are .