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Báo cáo khoa học: " Experimental concepts for toxicity prevention and tissue restoration after central nervous system irradiation"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Radiation Oncology cung cấp cho các bạn kiến thức về ngành y đề tài: " Experimental concepts for toxicity prevention and tissue restoration after central nervous system irradiation. | Radiation Oncology BioMed Central Open Access Experimental concepts for toxicity prevention and tissue restoration after central nervous system irradiation Carsten Nieder 1 Nicolaus Andratschke2 and Sabrina T Astner2 Address Radiation Oncology Unit Nordlandssykehuset HF 8092 Bod0 Norway and 2Department of Radiation Oncology Klinikum rechts der Isar der Technischen Universitat Munchen Ismaninger Str. 22 81675 Munich Germany Email Carsten Nieder - carsten.nieder@nlsh.no Nicolaus Andratschke - radiotherapy@gmx.net Sabrina T Astner - sabrina.astner@gmx.de Corresponding author Published 30 June 2007 Received 30 March 2007 Radiation Oncology 2007 2 23 doi 10.1186 1748-717X-2-23 Accepted 30 June 2007 This article is available from http www.ro-journal.cOm content 2 1 23 2007 Nieder et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract__ Several experimental strategies of radiation-induced central nervous system toxicity prevention have recently resulted in encouraging data. The present review summarizes the background for this research and the treatment results. It extends to the perspectives of tissue regeneration strategies based for example on stem and progenitor cells. Preliminary data suggest a scenario with individually tailored strategies where patients with certain types of comorbidity resulting in impaired regeneration reserve capacity might be considered for toxicity prevention while others might be salvaged by delayed interventions that circumvent the problem of normal tissue specificity. Given the complexity of radiation-induced changes single target interventions might not suffice. Future interventions might vary with patient age elapsed .