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Báo cáo y học: "The quest for the Holy Grail: a disease-modifying osteoarthritis drug"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: The quest for the Holy Grail: a disease-modifying osteoarthritis drug. | Available online http arthritis-research.eom content 9 6 111 Editorial The quest for the Holy Grail a disease-modifying osteoarthritis drug Francis Berenbaum1 2 1 Department of Rheumatology APHP Saint-Antoine Hospital 184 rue du faubourg Saint-Antoine 75012 Paris France 2UMR 7079 CNRS Physiology and Physiopathology Laboratory University Paris 6 Quai St-Bernard Paris 75252 Cedex 5 France Corresponding author Francis Berenbaum francis.berenbaum@sat.aphp.fr Published 10 December 2007 This article is online at http arthritis-research.com content 9 6 111 2007 BioMed Central Ltd Arthritis Research Therapy 2007 9 111 doi 10.1186 ar2335 See related research by Krzeski et al. http arthritis-research.com content 9 5 R109 Abstract The unfortunate story of the matrix metalloproteinase inhibitor PG116800 which had no effect on the osteoarthritic process but had unexpected side effects highlights the following. First reality does not always match the theory. Second cell biology data must be interpreted within the context of a specific environment. Third the specificity of an enzyme inhibitor is always relative. Finally a critical evaluation of the benefit risk ratio of a drug must be carefully conducted and checked before and after launch. Well designed post-marketing surveillance is mandatory. The process leading to the discovery of a new drug has completely changed during the past few years. Most therapeutic molecules launched before the 1990s were discovered by unsophisticated screening tests or by chance without any hypothesis as to their mechanism of action. Studies on mechanism were usually performed after the drug had appeared on the market sometimes many years after its commercialization. The late 20th century saw the beginning of unparalleled advances in the field of molecular biology that have turned drug discovery upside down. Drug development is now based on basic research findings such as the effects of over-expression or deletion of genes encoding novel proteins or