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Báo cáo y học: "Anti-inflammatory effect of antidiabetic thiazolidinediones prevents bone resorption rather than cartilage changes in experimental polyarthritis"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Anti-inflammatory effect of antidiabetic thiazolidinediones prevents bone resorption rather than cartilage changes in experimental polyarthritis. | Available online http arthritis-research.eom content 10 1 R6 Research article Anti-inflammatory effect of antidiabetic thiazolidinediones prevents bone resorption rather than cartilage changes in experimental polyarthritis Meriem Koufany1 David Moulin1 Arnaud Bianchi1 Mikhaela Muresan2 Sylvie Sebillaud1 Patrick Netter1 Georges Weryha2 and Jean-Yves Jouzeau1 1Laboratoire de Physiopathologie et Pharmacologie Articulaires LPPA UMR 7561 CNRS-Nancy Université avenue de la forêt de Haye BP 184 54505 Vandoeuvre-lès-Nancy France 2Centre Hospitalier Régional et Universitaire Service d Endocrinologie Médecine E rue du Morvan 54511 Vandoeuvre-lès-Nancy France Corresponding author Jean-Yves Jouzeau jouzeau@medecine.uhp-nancy.fr Received 18 Jul 2007 Revisions requested 29 Aug 2007 Revisions received 27 Nov 2007 Accepted 16 Jan 2008 Published 16 Jan 2008 Arthritis Research Therapy 2008 10 R6 doi 1 0.1186 ar2354 This article is online at http arthritis-research.com content 10 1 R6 2008 Koufany et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Open Access Abstract Background Rosiglitazone and pioglitazone are high-affinity peroxisome proliferator-activated receptor PPAR -Y agonists with potent anti-diabetic properties and potential antiinflammatory effects. We compared the ability of a range of oral doses of these thiazolidinediones including those sufficient to restore insulin sensitization to inhibit the pathogenesis of adjuvant-induced arthritis AIA . Methods AIA was induced in Lewis rats by a subcutaneous injection of 1 mg of complete Freund s adjuvant. Rats were treated orally for 21 days with pioglitazone 3 10 or 30 mg kg day rosiglitazone 3 or 10 mg kg day or with vehicle only. The time course of AIA was evaluated by .