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Báo cáo y học: "Indoleamine 2,3-dioxygenase-expressing dendritic cells are involved in the generation of CD4+CD25+ regulatory T cells in Peyer's patches in an orally tolerized, collagen-induced arthritis mouse model"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Indoleamine 2,3-dioxygenase-expressing dendritic cells are involved in the generation of CD4+CD25+ regulatory T cells in Peyer's patches in an orally tolerized, collagen-induced arthritis mouse model. | Available online http arthritis-research.eom content 10 1 R11 Research article Indoleamine 2 3-dioxygenase-expressing dendritic cells are involved in the generation of CD4 CD25 regulatory T cells in Peyer s patches in an orally tolerized collagen-induced arthritis mouse model Min-Jung Park1 So-Youn Min1 Kyung-Su Park1 2 Young-Gyu Cho1 Mi-La Cho1 Young-Ok Jung1 Hyun-Sil Park1 Soog-Hee Chang1 Seok Goo Cho3 Jun-Ki Min1 2 Sung-Hwan Park1 2 and Ho-Youn Kim1 2 Open Access 1The Rheumatism Research Center Catholic Research Institute of Medical Science The Catholic University of Korea Banpo-dong Seocho-gu Seoul 137-701 South Korea 2Center for Rheumatic Disease Division of Rheumatology Department of Internal Medicine Kangnam St Mary s Hospital The Catholic University of Korea Banpo-dong Seocho-gu Seoul 137-701 South Korea 3Department of Hematology Catholic Hematopoietic Stem Cell Transplantation Youido St Mary s Hospital. The Catholic University of Korea Youido-dong Youngdungpo-Gu Seoul 150-713 South Korea Contributed equally Corresponding author Ho-Youn Kim ho0919@catholic.ac.kr Received 12 Apr 2007 Revisions requested 16 May 2007 Revisions received 17 Jan 2008 Accepted 25 Jan 2008 Published 25 Jan 2008 Arthritis Research Therapy 2008 10 R11 doi 10.1186 ar2361 This article is online at http arthritis-research.com content 10 1 R11 2008 Park et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Introduction The present study was devised to understand the role of systemic indoleamine 2 3-dioxygenase IDO in the tolerance induction for orally tolerized mice in collagen-induced arthritis CIA . We examined whether IDO-expressing dendritic cells DCs are involved in the generation of CD4 CD25 regulatory T cells during the induction