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Weekly intra-articular injections of bone morphogenetic protein-7 inhibits osteoarthritis progression

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Collection of reports on medical research published in medical journals General Psychiatry provides medical knowledge about your subject: Weekly intra-articular injections of bone morphogenetic protein-7 inhibits osteoarthritis progression . | Available online http arthritis-research.eom content 10 5 R118 Research article Weekly intra-articular injections of bone morphogenetic protein-7 inhibits osteoarthritis progression Masaya Hayashi1 Takeshi Muneta1 Young-Jin Ju1 Tomoyuki Mochizuki2 and Ichiro Sekiya2 Section of Orthopaedic Surgery Graduate School Tokyo Medical and Dental University Yushima Bunkyo-ku Tokyo 113-851 9 Japan 2Section of Cartilage Regeneration Graduate School Tokyo Medical and Dental University Yushima Bunkyo-ku Tokyo 113-8519 Japan Corresponding author Ichiro Sekiya sekiya.orj@tmd.ac.jp Received 28 Nov 2007 Revisions requested 18 Jan 2008 Revisions received 4 Sep 2008 Accepted 30 Sep 2008 Published 30 Sep 2008 Arthritis Research Therapy 2008 10 R118 doi 10.1186 ar2521 This article is online at http arthritis-research.com content 10 5 R118 2008 Hayashi et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Open Access Abstract Introduction We investigated the ability of a weekly intraarticular injection of bone morphogenetic protein BMP -7 to prevent osteoarthritis in rabbits with anterior cruciate ligament transections. Methods First 36 knee joints were randomly divided into four groups 50 500 5 000 ng BMP-7 and control. Knee cartilage was evaluated at 4 8 and 12 weeks. Then in order to control for individual differences 500 ng BMP-7 was injected into one knee and phosphate-buffered saline PBS into the other and the two knees were compared at 4 8 and 12 weeks n 5 . For pharmacokinetic analysis cartilage was harvested at 1 hour and 1 2 4 and 7 days after knee injection of 500 ng BMP-7 or PBS n 3 . Results Histological scores in the 500 and 5 000 ng BMP-7 groups were significantly better than those in the other groups at 12 weeks. Matched pair .