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Báo cáo y học: "Trends towards an improved disease state in rheumatoid arthritis over time: influence of new therapies and changes in management approach: analysis of the EMECAR cohort"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Trends towards an improved disease state in rheumatoid arthritis over time: influence of new therapies and changes in management approach: analysis of the EMECAR cohort. | Available online http arthritis-research.eom content 10 6 R138 Open Access Research article Trends towards an improved disease state in rheumatoid arthritis over time influence of new therapies and changes in management approach analysis of the EMECAR cohort Isidoro Gonzalez-Alvaro1 Miguel Angel Descalzo2 Loreto Carmona2 for the EMECAR Study Group Rheumatology Service Hospital Universitario de la Princesa c Diego de León 62 Madrid 28006 Spain 2Research Unit Fundación Espanola de Reumatología c Marques del Duero 5 1 Madrid 28001 Spain Corresponding author Isidoro Gonzalez-Alvaro isidoro.ga@ser.es Received 3 Jul 2008 Revisions requested 2 Sep 2008 Revisions received 2 Oct 2008 Accepted 26 Nov 2008 Published 26 Nov 2008 Arthritis Research Therapy 2008 10 R138 doi 10.11 86 ar2561 This article is online at http arthritis-research.com content 10 6 R138 2008 Gonzalez-Alvaro et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Introduction The disease activity in patients with rheumatoid arthritis has improved during the past decade. The availability of new drugs and also a better assessment of the disease have been proposed to be responsible for this improvement. In the present work we estimate the effect of these factors on disease activity and function in patients with rheumatoid arthritis at the beginning of the new century. Methods The Estudio de la Morbilidad y Expresión Clínica de la Artritis Reumatoide EMECAR cohort was assembled in 2000 from the random sampling of rheumatoid arthritis patients registered in 34 centers. The cohort was composed of 789 patients who underwent a baseline assessment plus four annual follow-up visits in which functional ability Health Assessment Questionnaire score the disease activity