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Báo cáo y học: " Implication of granulocyte-macrophage colony-stimulating factor induced neutrophil gelatinase-associated lipocalin in pathogenesis of rheumatoid arthritis revealed by proteome analysis"

Tham khảo luận văn - đề án 'báo cáo y học: " implication of granulocyte-macrophage colony-stimulating factor induced neutrophil gelatinase-associated lipocalin in pathogenesis of rheumatoid arthritis revealed by proteome analysis"', luận văn - báo cáo phục vụ nhu cầu học tập, nghiên cứu và làm việc hiệu quả | Available online http arthritis-research.eom content 11 1 R3 Research article Implication of granulocyte-macrophage colony-stimulating factor induced neutrophil gelatinase-associated lipocalin in pathogenesis of rheumatoid arthritis revealed by proteome analysis Masayoshi Katano1 2 Kazuki Okamoto3 Mitsumi Arito3 Yuki Kawakami3 Manae S Kurokawa3 Naoya Suematsu3 Sonoko Shimada1 Hiroshi Nakamura4 Yang Xiang5 Kayo Masuko3 Kusuki Nishioka1 Kazuo Yudoh1 and Tomohiro Kato1 3 Open Access institute of Medical Science St Marianna University School of Medicine 2-16-1 Sugao Miyamae-ku Kawasaki Kanagawa 216-0015 Japan 2Department of Advanced Medicine Development Mitsubishi Chemical Medience Corporation 4-2-8 Shibaura Minato-ku Tokyo 108-8559 Japan 3Clinical Proteomics Molecular Medicine St Marianna University Graduate School of Medicine 2-1 6-1 Sugao Miyamae-ku Kawasaki Kanagawa 216-0015 Japan 4Department of Joint Disease and Rheumatism Nippon Medical School 1-1-5 Sendagi Bunkyo-ku Tokyo 113-8602 Japan 5Department of Rheumatology and Immunology University Hospital Hubei University for Nationalities 11 Xueyuan Road Wuchang Wuhan Hubei 430062 PR China Corresponding author Tomohiro Kato t3kato@marianna-u.ac.jp Received 1 2 May 2008 Revisions requested 23 Jun 2008 Revisions received 3 Dec 2008 Accepted 8 Jan 2009 Published 8 Jan 2009 Arthritis Research Therapy 2009 11 R3 doi 1 0.1186 ar2587 This article is online at http arthritis-research.com content 11 1 R3 2009 Katano et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Introduction In rheumatoid arthritis RA synovial fluid SF contains a large number of neutrophils that contribute to the inflammation and destruction of the joints. The SF also contains granulocyte-macrophage .