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Báo cáo y học: "Treatment of focal degenerative cartilage defects with polymer-based autologous chondrocyte grafts: four-year clinical results"

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Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Treatment of focal degenerative cartilage defects with polymer-based autologous chondrocyte grafts: four-year clinical results. | Available online http arthritis-research.eom content 11 2 R33 Open Access Research article Treatment of focal degenerative cartilage defects with polymer-based autologous chondrocyte grafts four-year clinical results Peter C Kreuz1 Sebastian Muller2 Christian Ossendorf2 Christian Kaps3 and Christoph Erggelet2 Department of Orthopaedic and Trauma Surgery University Medical Center Rechts der Isar of the Technical University Munich Ismaninger Str. 22 81675 Munich Germany department of Orthopaedic and Trauma Surgery University Medical Center Freiburg Hugstetter Str. 55 79106 Freiburg Germany department of Rheumatology Charité Campus Mitte Charité - Universitatsmedizin Berlin Chariteplatz 1 10117 Berlin Germany Corresponding author Christian Kaps christian.kaps@charite.de Received 18 Sep 2008 Revisions requested 28 Oct 2008 Revisions received 4 Feb 2009 Accepted 5 Mar 2009 Published 5 Mar 2009 Arthritis Research Therapy 2009 11 R33 doi 10.1186 ar2638 This article is online at http arthritis-research.com content 11 2 R33 2009 Kreuz et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Introduction Second-generation autologous chondrocyte implantation with scaffolds stabilizing the grafts is a clinically effective procedure for cartilage repair. In this ongoing prospective observational case report study we evaluated the effectiveness of BioSeed -C a cell-based cartilage graft based on autologous chondrocytes embedded in fibrin and a stable resorbable polymer scaffold for the treatment of clinical symptomatic focal degenerative defects of the knee. Methods Clinical outcome after 4-year clinical follow-up was assessed in 19 patients with preoperatively radiologically confirmed osteoarthritis and a Kellgren-Lawrence score

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