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Báo cáo y học: "Asporin, a susceptibility gene in osteoarthritis, is expressed at higher levels in the more degenerate human intervertebral disc"

Available online http://arthritis-research.com/content/11/2/R47 Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài:Asporin, a susceptibility gene in osteoarthritis, is expressed at higher levels in the more degenerate human intervertebral disc. | Available online http arthritis-research.eom content 11 2 R47 Research article Asporin a susceptibility gene in osteoarthritis is expressed at higher levels in the more degenerate human intervertebral disc Helen E Gruber Jane A Ingram Gretchen L Hoelscher Natalia Zinchenko Edward N Hanley Jr and Yubo Sun Department of Orthopedic Surgery Carolinas Medical Center PO Box 32861 Charlotte NC 28232 USA Corresponding author Helen E Gruber helen.gruber@carolinashealthcare.org Received 23 Dec 2008 Revisions requested 9 Feb 2009 Revisions received 11 Feb 2009 Accepted 27 Mar 2009 Published 27 Mar 2009 Arthritis Research Therapy 2009 11 R47 doi 10.1186 ar2660 This article is online at http arthritis-research.com content 11 2 R47 2009 Gruber et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Open Access Abstract Introduction Asporin also known as periodontal ligament-associated protein 1 PLAP1 is a member of the family of small leucine-rich proteoglycan SLRP family. It is present within the cartilage extracellular matrix ECM and is reported to have a genetic association with osteoarthritis. Its D14 allele has recently been found to be associated with lumbar disc degeneration in Asian subjects. There have been no studies however of this gene s normal immunohistochemical localization within the human intervertebral disc or of expression levels in Caucasian individuals with disc degeneration. Methods Studies were approved by our human subjects Institutional Review Board. Methods included immunohistochemical localization of asporin in the disc of humans and the sand rat a small rodent with spontaneous age-related disc degeneration and Affymetrix microarray analysis of asporin gene expression in vivo and in vitro. Results .