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Báo cáo y học: "Spondyloarthritis: lessons from imaging"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Spondyloarthritis: lessons from imaging. | Available online http arthritis-research.eom content 11 3 222 Review Progress in spondylarthritis Spondyloarthritis lessons from imaging Walter P Maksymowych1 2 1 Department of Medicine 562 Heritage Medical Research Building University of Alberta Edmonton Alberta T6G 2S2 Canada 2Alberta Heritage Foundation for Medical Research Alberta Canada Corresponding author Walter P Maksymowych walter.maksymowych@ualberta.ca Published 18 May 2009 This article is online at http arthritis-research.com content 11 3 222 2009 BioMed Central Ltd Arthritis Research Therapy 2009 11 222 doi 10.1186 ar2665 Abstract The advent of magnetic resonance imaging MRI and advanced sonographic techniques has led to a resurgence of interest in the role of imaging in the evaluation and management of spondylo-arthritis. Radiography remains the cornerstone of diagnosis although MRI is more sensitive in early stages of the disease. Inflammatory changes in the sacroiliac joints and spine can now be reliably quantified and can also predict the subsequent development of radiographic changes in the corresponding locations. MRI-based scoring systems for inflammation are highly responsive facilitating proof-of-concept studies of new therapies for spondylo-arthritis. Assessment of chronic changes is much less reliable using MRI while assessment using radiography lacks sensitivity to change. Assessment of disease modification therefore remains a principle challenge in the development of new therapies for ankylosing spondylitis. Ultrasound may be the preferred approach to the assessment of peripheral inflammation especially enthesitis. Scintigraphy and computed tomography offer few advantages over MRI. Introduction Spondyloarthritis SpA is a group of inflammatory disorders that primarily affect the sacroiliac joint SIJ structures of the spine large peripheral joints and entheses that are associated with the HLA-B27 gene. Most clinicians still use imaging primarily to evaluate structural abnormalities in the .