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Báo cáo y học: "The quest for a biomarker of circulating osteoclast precursors"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: The quest for a biomarker of circulating osteoclast precursors. | Available online http arthritis-research.eom content 11 3 113 Editorial The quest for a biomarker of circulating osteoclast precursors Christopher Ritchlin University of Rochester Medical Center Rochester NY 14642 USA Corresponding author Christopher Ritchlin christopher_ritchlin@urmc.rochester.edu Published 17 June 2009 Arthritis Research Therapy 2009 11 113 doi 10.1186 ar2707 This article is online at http arthritis-research.com content 11 3 113 2009 BioMed Central Ltd See related research by Lari et al. http arthritis-research.com content 11 1 R23 Abstract Osteoclast precursors arise from the CD14 CD16- population in controls but details about cell surface marker expression and functional characteristics of these cells is unknown particularly in patients with inflammatory arthritis. In a recent issue of Arthritis Research and Therapy Lari and colleagues found that osteoclasts developed from a proliferative CD14 CD16- subset in healthy controls. These cells took on the morphology of osteoclasts expressed mRNA for osteoclast-related genes and excavated pits on bone wafers. These findings provide new insights into monocyte diversity and provide evidence that osteoclast precursors arise from a small proliferating monocyte population in controls. Additional studies are needed in patients with inflammatory arthritis .Since these cells aside from their capacity to stretch out prolongations also are capable of consuming foreign bodies we will subsume them under the joint name of fagocytes sic . Ellie Metchnikoff 1884 In a recent issue of Arthritis Research and Therapy Lari and colleagues provide evidence that osteoclast precursors arise from a novel subset of proliferating monocytes 1 . Research in this area originated with the seminal observations of Metchnikoff regarding the central importance of phagocytosis to human physiology which culminated in a Noble Prize and laid the groundwork for the field of innate immunity at the opening of the last century 2 . Macrophages