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Báo cáo y học: "Degradome expression profiling in human articular cartilage"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Degradome expression profiling in human articular cartilage. | Available online http arthritis-research.eom content 11 3 R96 Research article Degradome expression profiling in human articular cartilage Tracey E Swingler1 Jasmine G Waters1 Rosemary K Davidson1 Caroline J Pennington1 Xose S Puente2 Clare Darrah3 Adele Cooper3 Simon T Donell3 Geoffrey R Guile4 Wenjia Wang4 and Ian M Clark1 1School of Biological Sciences University of East Anglia Earlham Road Norwich NR4 7TJ UK 2Departamento de Bioquímica y Biología Molecular Facultad de Medicina Universidad de Oviedo 33006 Oviedo Spain institute of Orthopaedics Norfolk Norwich University Hospital Colney Lane Norwich NR4 7UY UK 4School of Computing Sciences University of East Anglia Earlham Road Norwich NR4 7TJ UK Corresponding author Ian M Clark i.clark@uea.ac.uk Received 16 Apr 2009 Revisions requested 4 Jun 2009 Revisions received 10 Jun 2009 Accepted 23 Jun 2009 Published 23 Jun 2009 Arthritis Research Therapy 2009 11 R96 doi 10.1186 ar2741 This article is online at http arthritis-research.com content 11 3 R96 2009 Swingler et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Open Access Abstract Introduction The molecular mechanisms underlying cartilage destruction in osteoarthritis are poorly understood. Proteolysis is a key feature in the turnover and degradation of cartilage extracellular matrix where the focus of research has been on the metzincin family of metalloproteinases. However there is strong evidence to indicate important roles for other catalytic classes of proteases with both extracellular and intracellular activities. The aim of this study was to profile the expression of the majority of protease genes in all catalytic classes in normal human cartilage and that from patients with osteoarthritis OA using a .