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Báo cáo y học: "Progress in osteoporosis and fracture prevention: focus on postmenopausal women"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Progress in osteoporosis and fracture prevention: focus on postmenopausal women. | Available online http arthritis-research.eom content 11 5 251 Review Progress in osteoporosis and fracture prevention focus on postmenopausal women Kenneth G Saag1 and Piet Geusens2 1 Division of Clinical Immunology and Rheumatology Center for Education and Research on Therapeutics University of Alabama at Birmingham 820 Faculty Office Tower 510 20th Street South Birmingham AL 35294-3708 USA 2Department of Internal Medicine Subdivision of Rheumatology Maastricht University Medical Center P. Debyelaan 25 Postbus 5800 6202 AZ Maastricht The Netherlands Biomedical Research Institute University Hasselt Agoralaan gebouw D B-3590 Diepenbeek Belgium Corresponding author Kenneth G Saag ksaag@uab.edu Published 14 October 2009 This article is online at http arthritis-research.com content 11 5 251 2009 BioMed Central Ltd Arthritis Research Therapy 2009 11 251 doi 10.1186 ar2815 Abstract In the past decade we have witnessed a revolution in osteoporosis diagnosis and therapeutics. This includes enhanced understanding of basic bone biology recognizing the severe consequences of fractures in terms of morbidity and short-term refracture and mortality risk and case finding based on clinical risks bone mineral density new imaging approaches and contributors to secondary osteoporosis. Medical interventions that reduce fracture risk include sufficient calcium and vitamin D together with a wide spectrum of drug therapies with antiresorptive anabolic or mixed effects . Emerging therapeutic options that target molecules of bone metabolism indicate that the next decade should offer even greater promise for further improving our diagnostic and treatment approaches. Introduction In the past decade we have witnessed a revolution in understanding bone biology. Major progress has also been achieved in fracture risk estimation and prevention of fractures. How does this progress translate into daily clinical practice First case finding of subjects at highest risk for fractures is now possible at