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Báo cáo y học: "Phenotypic and functional characterization of switch memory B cells from patients with oligoarticular juvenile idiopathic arthritis"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Phenotypic and functional characterization of switch memory B cells from patients with oligoarticular juvenile idiopathic arthritis. | Available online http arthritis-research.eom content 11 5 R150 Research article Phenotypic and functional characterization of switch memory B cells from patients with oligoarticular juvenile idiopathic arthritis Anna Corcione1 Francesca Ferlito2 3 Marco Gattorno2 3 Andrea Gregorio4 Angela Pistorio5 Roberto Gastaldi3 6 Claudio Gambini4 Alberto Martini2 3 Elisabetta Traggiai2 3 and Vito Pistoia1 Laboratory of Oncology IRCCS G. Gaslini Largo G. Gaslini 5 Genoa 16148 Italy 2Second Division of Pediatrics IRCCS G. Gaslini Largo G. Gaslini 5 Genoa 16148 Italy 3University of Genoa Viale Benedetto XV Genoa 16100 Italy 4Human Anatomy Section IRCCS G. Gaslini Largo G. Gaslini 5 Genoa 16148 Italy 5Clinical Epidemiology and Biostatistics Unit Scientific Direction IRCCS G. Gaslini Institute Largo G. Gaslini 5 Genoa 16148 Italy 6IRCCS G. Gaslini Largo G. Gaslini 5 Genoa 16148 Italy Contributed equally Corresponding author Anna Corcione annacorcione@ospedale-gaslini.ge.it Received 26 Jan 2009 Revisions requested 1 2 Mar 2009 Revisions received 9 Sep 2009 Accepted 5 Oct 2009 Published 5 Oct 2009 Arthritis Research Therapy 2009 11 R150 doi 10.11 86 ar2824 This article is online at http arthritis-research.com content 11 5 R150 2009 Corcione et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 20 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Open Access Abstract Introduction In chronic inflammatory disorders B cells can contribute to tissue damage by autoantibody production and antigen presentation to T cells. Here we have characterized synovial fluid and tissue B-cell subsets in patients with oligoarticular juvenile idiopathic arthritis JIA an issue not addressed before in detail. Methods B cells from synovial fluid SF and peripheral blood PB of 25 JIA patients as well as from PB of 20 .