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Báo cáo y học: "Inflammatory changes in the airways of mice caused by cigarette smoke exposure are only partially reversed after smoking cessation"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài:Inflammatory changes in the airways of mice caused by cigarette smoke exposure are only partially reversed after smoking cessation. | Braber et al. Respiratory Research 2010 11 99 http respiratory-research.eom content 11 1 99 RESPIRATORY RESEARCH RESEARCH Open Access Inflammatory changes in the airways of mice caused by cigarette smoke exposure are only partially reversed after smoking cessation Saskia Braber Paul AJ Henricks Frans P Nijkamp Aletta D Kraneveld Gert Folkerts Abstract Background Tobacco smoking irritates and damages the respiratory tract and contributes to a higher risk of developing lung emphysema. At present smoking cessation is the only effective treatment for reducing the progression of lung emphysema however there is hardly anything known about the effects of smoking cessation on cytokine and chemokine levels in the airways. To the best of our knowledge this is the first reported in vivo study in which cytokine profiles were determined after cessation of cigarette smoke exposure. Methods The severity of airway remodeling and inflammation was studied by analyzing alveolar enlargement heart hypertrophy inflammatory cells in the bronchoalveolar lavage fluid BALF and lung tissue and by determining the cytokine and chemokine profiles in the BALF of A J mice exposed to cigarette smoke for 20 weeks and 8 weeks after smoking cessation. Results The alveolar enlargement and right ventricle heart hypertrophy found in smoke-exposed mice remained unchanged after smoking cessation. Although the neutrophilic inflammation in the BALF of cigarette smoke-exposed animals was reduced after smoking cessation a sustained inflammation in the lung tissue was observed. The elevated cytokine IL-1a and TNF-a and chemokine CCL2 and CCL3 levels in the BALF of smoke-exposed mice returned to basal levels after smoking cessation while the increased IL-12 levels did not return to its basal level. The cigarette smoke-enhanced VEGF levels did not significantly change after smoking cessation. Moreover IL-10 levels were reduced in the BALF of smoke-exposed mice and these levels were still significantly decreased