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Báo cáo y học: " CTLA4-Ig interacts with cultured synovial macrophages from rheumatoid arthritis patients and downregulates cytokine production"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: CTLA4-Ig interacts with cultured synovial macrophages from rheumatoid arthritis patients and downregulates cytokine production. | Available online http arthritis-research.eom content 11 6 R176 Research article CTLA4-Ig interacts with cultured synovial macrophages from rheumatoid arthritis patients and downregulates cytokine production Maurizio Cutolo1 Stefano Soldano1 Paola Montagna1 Alberto Sulli1 Bruno Seriolo1 Barbara Villaggio2 Pierfranco Triolo3 Paolo Clerico3 Lamberto Felli4 and Renata Brizzolara1 Research Laboratories and Academic Unit of Clinical Rheumatology Department of Internal Medicine University of Genova Viale Benedetto XV 16132 Genova Italy 2Clinical Academic Unit of Nephrology Department of Internal Medicine University of Genova Viale Benedetto XV 16132 Genova Italy 3Rheumatoid Arthritis Unit - Orthopedic Surgery Department CTO Hospital Via Zuretti 10126 Turin Italy 4Orthopedic Department Largo Rosanna Benzi University of Genova 16132 Genova Italy Corresponding author Maurizio Cutolo mcutolo@unige.it Received 28 Mar 2009 Revisions requested 27 Apr 2009 Revisions received 4 Nov 2009 Accepted 23 Nov 2009 Published 23 Nov 2009 Arthritis Research Therapy 2009 11 R176 doi 10.11 86 ar2865 This article is online at http arthritis-research.com content 11 6 R176 2009 Cutolo et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Open Access Abstract Introduction Co-stimulatory signal B7 CD80 CD86 CD28 is needed in order to activate T cells in immune response. Cytotoxic T lymphocyte-associated antigen-4-immunoglobulin CTLA4-Ig binding to the B7 molecules on antigen-presenting cells downregulates this activation and represents a recent biological treatment in rheumatoid arthritis RA . Objectives of the study were to investigate the presence of the B7.2 CD86 molecule and its masking by CTLA4-Ig on cultures of both RA synovial macrophages RA SM and