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Báo cáo y học: "A combination of methotrexate and zoledronic acid prevents bone erosions and systemic bone mass loss in collagen induced arthritis"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: A combination of methotrexate and zoledronic acid prevents bone erosions and systemic bone mass loss in collagen induced arthritis. | Available online http arthritis-research.eom content 11 6 R185 Research article A combination of methotrexate and zoledronic acid prevents bone erosions and systemic bone mass loss in collagen induced arthritis Benoit Le Goff1 2 3 Elise Soltner1 2 3 Céline Charrier1 2 Yves Maugars3 Frangoise Rédini1 2 Dominique Heymann1 2 3 4 and Jean-Marie Berthelot1 2 3 1INSERM UMR-S 957 1 rue Gaston Veil 44035 Nantes Cedex 1 France 2Université de Nantes Nantes atlantique universités Laboratoire de Physiopathologie de la Résorption Osseuse et Thérapie des Tumeurs Osseuses Primitives EA3822 1 rue Gaston Veil 44035 Nantes Cedex 1 France 3Rheumatology Unit Hôtel-Dieu Nantes University Hospital 1 place Alexis Ricordeau 44093 Nantes Cedex 1 France 4Pôle de Biologie Hotel Dieu Nantes University Hospital 1 place Alexis Ricordeau 44093 Nantes Cedex 1 France Corresponding author Benoit Le Goff benlegoff@gmail.com Received 1 Aug 2009 Revisions requested 29 Sep 2009 Revisions received 3 Dec 2009 Accepted 10 Dec 2009 Published 10 Dec 2009 Arthritis Research Therapy 2009 11 R185 doi 10.11 86 ar2877 This article is online at http arthritis-research.com content 11 6 R185 2009 Le Goff et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Open Access Abstract Introduction Osteoclasts play a key role in the pathogenesis of bone erosion and systemic bone mass loss during rheumatoid arthritis RA . In this study we aimed to determine the effect of methotrexate MTX and zoledronic acid ZA used alone or in combination on osteoclast-mediated bone erosions and systemic bone mass loss in a rat model of collagen induced arthritis CIA . We hypothesized that MTX and ZA could have an additive effect to prevent both bone erosion and systemic bone loss. Methods .