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Báo cáo y học: "Correlation of pain relief with physical function in hand osteoarthritis: randomized controlled trial post hoc analysis"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Correlation of pain relief with physical function in hand osteoarthritis: randomized controlled trial post hoc analysis. | Barthel et al. Arthritis Research Therapy 2010 12 R7 http arthritis-research.eom content 12 1 R7 RESEARCH ARTICLE Open Access Correlation of pain relief with physical function in hand osteoarthritis randomized controlled trial post hoc analysis HKA D T I I 1 I I I_I D 11 h r 2 ft t Tfil D I T V ỉs3 l V ri c c AS I 14 D ỉ I Ì A I 5 Richard Barthel John H Peniston Michael B Clark Morris S Gold Roy D Altman Abstract Introduction Nonsteroidal anti-inflammatory drugs are recommended for the relief of pain associated with hand osteoarthritis OA but do not alter the underlying structural changes that contribute to impaired physical function. The current analysis examined the relationship of pain relief with measures of function and global rating of disease in patients with hand OA. Methods This was a combined analysis of 2 prospective randomized double-blind 8-weeK multicenter parallel-group studies comparing diclofenac sodium 1 gel with placebo gel vehicle in patients with radiographically confirmed mild to moderate hand OA. Patients n 783 aged 40 years applied diclofenac sodium 1 gel 2 g or vehicle to each hand 4 times daily for 8 weeks. Outcome measures included pain intensity assessed on a 100mm Visual Analog Scale VAS the Australian Canadian Osteoarthritis Hand Index AUSCAN subscales for pain stiffness and physical function 100-mm VAS and a global rating of disease 100-mm VAS . Change in VAS pain intensity from baseline to week 8 was categorized 0 0 - 15 15 - 30 30 - 50 50 - 70 and 70 without regard to treatment and compared in each category with the mean change from baseline in each AUSCAN subindex and the global rating of disease. Pearson correlations between changes in outcome measures from baseline to week 8 were calculated. Results Changes in VAS pain intensity were accompanied by similar changes in AUSCAN scores and global rating of disease. Pearson correlations confirmed significant associations P 0.001 between change in VAS pain intensity and changes in .